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      Merck Begins Phase 2b/3 Trial for New Treatment of Neovascular Age-Related Macular Degeneration

      Merck has announced the start of a pivotal Phase 2b/3 clinical trial for MK-8748, also known as Tiespectus. This investigational bispecific antibody is designed to activate Tie2 signaling while inhibiting vascular endothelial growth factor (VEGF), targeting neovascular age-related macular degeneration (NVAMD).

      The trial aims to evaluate the efficacy and safety of Tiespectus in patients suffering from this condition, which is characterized by the growth of abnormal blood vessels in the retina, leading to vision loss. Merck's research represents a significant step forward in the search for effective treatments for NVAMD, a leading cause of blindness in older adults.

      Merck, known as MSD in markets outside the United States and Canada, continues to advance its portfolio of therapies aimed at addressing serious eye diseases. The initiation of this trial underscores the company's commitment to developing innovative solutions for patients with unmet medical needs.

      © 2026 KLEA News. All Rights Reserved. This article is provided for informational purposes only. It is not offered or intended to be used as legal, tax, investment, financial, or other advice.

      Source: KLEA News

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